Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models

Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models

Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen. While the Spike protein is highly immunogenic, it is also subject to genetic drift over time, which has led to a series of variants of concern t...

Full description

Saved in:
Bibliographic Details
Main Authors: Jacob Meza, Elizabeth Glass, Avinaash K. Sandhu, Yangchen Li, Styliani Karanika, Kaitlyn Fessler, Yinan Hui, Courtney Schill, Tianyin Wang, Jiaqi Zhang, Rowan E. Bates, Alannah D. Taylor, Aakanksha R. Kapoor, Samuel K. Ayeh, Petros C. Karakousis, Richard B. Markham, James T. Gordy
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Vaccines
Subjects:
ORF3a
SARS-CoV-2
COVID-19
MIP3?/CCL20
DNA vaccine
KLH
Online Access:https://www.mdpi.com/2076-393X/13/3/220
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2076-393X/13/3/220

Similar Items