Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis

Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis

Summary: Cystic fibrosis (CF) is an autosomal recessive disease characterized by microbial infection and progressive decline in lung function, leading to significant morbidity and mortality. The bitter taste receptor T2R14 is a chemosensory receptor that is significantly expressed in airways. Using...

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Main Authors: Nisha Singh, Ryan H. Cunnington, Anjali Bhagirath, Ankita Vaishampayan, Mohd Wasif Khan, Tejas Gupte, Kangmin Duan, Abdelilah S. Gounni, Shyamala Dakshisnamurti, John W. Hanrahan, Prashen Chelikani
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Pathophysiology
Immunology
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025112
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http://www.sciencedirect.com/science/article/pii/S2589004224025112

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