Synergistic protective effects of TCM formula NRICM102 and N-acetylcysteine against hepatorenal injury in a mouse model of bongkrekic acid poisoning

Synergistic protective effects of TCM formula NRICM102 and N-acetylcysteine against hepatorenal injury in a mouse model of bongkrekic acid poisoning

Bongkrekic acid (BKA), a mitochondrial toxin produced by Burkholderia cocovenenans subsp. farinofermentans, is typically found in contaminated fermented rice products such as tempeh bongkrek, causing severe foodborne illnesses marked by systemic inflammation, multi-organ failure (MOF), and high mort...

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Main Authors: Yuh-Chiang Shen, Yea-Hwey Wang, Kuo-Tong Liou, Wen-Chi Wei, Jing-Jy Cheng, Hui-Kang Liu, Nai-Kuei Huang, I-Wen Lo, Cher-Chia Chang, Wen-Fei Chiou, Keng-Chang Tsai, Chun-Tang Chiou, Chia-Ching Liaw, Yi-Chang Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Bongkrekic acid
multi-organ failure
NRICM102
N-acetylcysteine
food poisoning
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596785/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1596785/full

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