Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

The Zika virus (ZIKV) outbreak and its link to microcephaly triggered a public health concern. To examine antibody response in a patient infected with ZIKV, we used single-cell PCR to clone 31 heavy and light chain-paired monoclonal antibodies (mAbs) that bind to ZIKV envelope (E) proteins isolated...

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Main Authors: Xuefeng Niu, Lingzhai Zhao, Linbing Qu, Zhipeng Yao, Fan Zhang, Qihong Yan, Shengnan Zhang, Renshan Liang, Peihai Chen, Jia Luo, Wei Xu, Huibin Lv, Xinglong Liu, Hui Lei, Changhua Yi, Pingchao Li, Qian Wang, Yang Wang, Lei Yu, Xiaoyan Zhang, L. Aubrey Bryan, Edgar Davidson, j. Benjamin Doranz, Liqiang Feng, Weiqi Pan, Fuchun Zhang, Ling Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Zika virus
monoclonal antibody
animal model
neutralizing epitopes
therapeutics
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1614885
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https://www.tandfonline.com/doi/10.1080/22221751.2019.1614885

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