Unraveling the genetic blueprint of doxorubicin-induced cardiotoxicity through systems genetics approaches

Abstract Background Anthracycline-induced cardiotoxicity (ACT) is a significant concern for cancer survivors, while genetic basis of ACT remains unclear. This study employs a murine genetic reference population (GRP) of BXD recombinant inbred strains, derived from DBA/2J (D2) and C57BL/6J (B6) cross...

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Main Authors: Buyan-Ochir Orgil, Akhilesh K. Bajpai, Neely Alberson, Morgan Lander, Batsaikhan Enkhzul, Hugo R. Martinez, Jeffrey A. Towbin, Lu Lu, Enkhsaikhan Purevjav
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cardio-Oncology
Online Access:https://doi.org/10.1186/s40959-025-00349-y
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