Computer-guided design of novel nitrogen-based heterocyclic sphingosine-1-phosphate (S1P) activators as osteoanabolic agents

Computer-guided design of novel nitrogen-based heterocyclic sphingosine-1-phosphate (S1P) activators as osteoanabolic agents

Osteoanabolic agents, or drugs that promote bone formation, have gained considerable attention for osteoporosis management due to their curative and preventive potentials. Sphingosine-1-phosphate receptor 2 (S1PR2) is an attractive drug target, in which its activation leads to osteogenesis-promoting...

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Bibliographic Details
Main Authors: Rattanawan Tangporncharoen, Chuleeporn Phanus-Umporn, Supaluk Prachayasittikul, Chanin Nantasenamat, Veda Prachayasittikul, Aungkura Supokawej
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2024-05-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
sphingosine-1-phosphate activators
quantitative structure-activity relationship
computer-aided drug design
osteoanabolic
quinoxalines
indoles
Online Access:https://www.excli.de/excli/article/view/7214
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https://www.excli.de/excli/article/view/7214

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