Positive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human.

Positive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human.

Bone Morphogenetic Protein 15 (BMP15) is a TGFβ-like oocyte-derived growth factor involved in ovarian folliculogenesis as a critical regulator of many granulosa cell processes. Alterations of the BMP15 gene have been found associated with different ovarian phenotypic effects depending on the species...

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Bibliographic Details
Main Authors: Sylvain Auclair, Raffaella Rossetti, Camille Meslin, Olivier Monestier, Elisa Di Pasquale, Géraldine Pascal, Luca Persani, Stéphane Fabre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0078199
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https://doi.org/10.1371/journal.pone.0078199

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