Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboring blaIMP-45 and blaVIM-1: an outbreak of Pseudomonas aeruginosa co-producing IMP-45 and VIM-1 carbapenemases in China

Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboring blaIMP-45 and blaVIM-1: an outbreak of Pseudomonas aeruginosa co-producing IMP-45 and VIM-1 carbapenemases in China

BackgroundCarbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant global health risk, particularly for immunocompromised individuals. This study documents an outbreak of CRPA strains co-harboring blaVIM-1 and blaIMP-45 on IncP-2 plasmids in a Chinese tertiary hospital, resulting in po...

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Bibliographic Details
Main Authors: Yiqun Ma, Zichen Lei, Yulin Zhang, Qi Liu, Feilong Zhang, Hao Zu, Xinrui Yang, Ziyao Li, Binghuai Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
carbapenem-resistant Pseudomonas aeruginosa
CRPA
horizontal gene transfer (HGT)
nosocomial infection
metallo-beta-lactamases (MBL)
resistance dissemination
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1623241/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1623241/full

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