Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism

Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism

Pancreatic cancer is a highly aggressive malignancy with a poor prognosis due to its complex tumor microenvironment (TME), which includes a dense extracellular matrix (ECM) and immunosuppressive pathways. Nanomedicine capable of achieving profound tumor penetration and modulating the tumor immune mi...

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Bibliographic Details
Main Authors: Meng Li, Danling Cheng, Yue Wang, Chongwen Xuan, Viktar Abashkin, Jindong Xia, Ling Ding, Jingchao Li
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Polymer nanoparticles
Sonodynamic therapy
Immunotherapy
Orthotopic pancreatic cancer
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005241
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