Effects of Obeticholic Acid Treatment on Primary Human Hepatocytes in a Novel Tri-Culture Model System

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing health concern worldwide. Human cell-based in vitro culture models that retain disease-relevant phenotypic pathways and responses to assess the efficacy and liability of new therapeutics are needed. Obeticholic Acid (OCA), a F...

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Bibliographic Details
Main Authors: Justin J. Odanga, Sharon M. Anderson, Edward L. LeCluyse, Sharon C. Presnell, Jingsong Chen, Jessica R. Weaver
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/14/13/968
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