Comparison of the Metabolic Profiles Associated with Protonitazene and Protonitazepyne in Two Severe Poisonings

Comparison of the Metabolic Profiles Associated with Protonitazene and Protonitazepyne in Two Severe Poisonings

Nitazenes represent an emerging class of new synthetic opioids characterized by a high-potency μ-opioid receptor (MOR) agonist activity. <b>Background</b>: We report two 20-year-old males who presented with severe neurorespiratory depression with typical opioid syndrome, but no opioid id...

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Bibliographic Details
Main Authors: Romain Magny, Thomas Schiestel, Aymen M’Rad, Bertrand Lefrère, Jean-Herlé Raphalen, Stanislas Ledochowski, Laurence Labat, Bruno Mégarbane, Pascal Houzé
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
protonitazene
nitazene
new synthetic opioid
high resolution mass spectrometry
molecular network
Online Access:https://www.mdpi.com/2218-1989/15/6/371
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