MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway

MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway

Abstract Ventilator induced lung injury (VILI) is caused by improper use of mechanical ventilation, and its pathogenesis remains unclear. The aim of this study was to establish animal and cell models of VILI, and to explore the mechanism of miR-125b-5p in alleviating VILI by inhibiting ferroptosis t...

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Bibliographic Details
Main Authors: Jiayi Zhang, Shuang He, Ke Wu, Yifan Wei, Chunyu Li, Qian Zhu, Siyu Lian, Li Wang, Fang Wan, Fuxiang Peng, Juan Zhang, Zongyu Chen, Xianming Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ventilator-induced lung injury
miR-125b-5p
Keap1
GPX4
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-04730-w
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https://doi.org/10.1038/s41598-025-04730-w

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