A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes

A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes

Abstract Glucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading to identification of numerous tissue-specific GR-dependent mechanis...

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Main Authors: Marcin Piechota, Mateusz Zieba, Małgorzata Borczyk, Slawomir Golda, Jacek Hajto, Urszula Skupio, Michal Slezak, Jan Rodriguez Parkitna, Michal Korostynski
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Glucocorticoid receptor
Dexamethasone
Tissue-specific transcription
Metabolic traits
Transcriptional regulation
Online Access:https://doi.org/10.1186/s12864-025-11676-w
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https://doi.org/10.1186/s12864-025-11676-w

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