The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective.

The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective.

To employ a reduced-order cardiovascular model as a digital twin for personalised medicine, it is essential to understand how uncertainties in the model's input parameters affect its outputs. The aim is to identify a set of input parameters that can serve as clinical biomarkers, providing insig...

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Main Authors: Harry Saxton, Daniel J Taylor, Grace Faulkner, Ian Halliday, Tom Newman, Torsten Schenkel, Paul D Morris, Richard H Clayton, Xu Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326112
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https://doi.org/10.1371/journal.pone.0326112

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