Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy

Enabling immune checkpoint blockade efficacy in T-lymphopenia by restoring CD8 T cell dynamics with IL-7 cytokine therapy

IntroductionT-lymphopenia (TLP) is a frequently observed condition in cancer patients, often exacerbated by conventional chemo/radiotherapy, which impairs the efficacy of subsequent immune checkpoint blockade (ICB) therapy. This study aimed to understand the impact of TLP on ICB responsiveness and e...

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Main Authors: Yeon-Woo Kang, Donghoon Choi, Dain Moon, Kun-Joo Lee, Youngsik Oh, Jaehyuk Yang, Siheon Jeong, Uni Park, Sun-Kyoung Im, Se Hwan Yang, Seung-Woo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
T-lymphopenia
treatment-related lymphopenia
interleukin-7
chemo/radiotherapy
tumor-infiltrating lymphocytes
tumor-reactive CD8 T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1477171/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1477171/full

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