Synthesis, structural elucidation, and antimicrobial evaluation of (2E)-3-(4-fluorophenyl)-1-(4-isopropylphenyl)prop-2-en-1-one: insights from experimental and computational studies

Synthesis, structural elucidation, and antimicrobial evaluation of (2E)-3-(4-fluorophenyl)-1-(4-isopropylphenyl)prop-2-en-1-one: insights from experimental and computational studies

Abstract The compound (2E)-3-(4-Fluorophenyl)-1-(4-isopropylphenyl)prop-2-en-1-one (FIPP) was synthesized via Claisen-Schmidt condensation and fully characterized using FT-IR, 1H and 13C NMR, HRMS, and single-crystal X-ray diffraction. HRMS analysis validated the molecular composition and purity, wh...

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Bibliographic Details
Main Authors: Nutan V. Sadgir, Vishnu A. Adole, Sunil L. Dhonnar, Bapu S. Jagdale, Kailas H. Kapadnis, Jayesh Pawar
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Chemistry
Subjects:
Claisen-Schmidt condensation
Single-crystal X-ray diffraction
DFT/B3LYP calculations
Antimicrobial activity
Molecular docking
Online Access:https://doi.org/10.1007/s44371-025-00195-y
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https://doi.org/10.1007/s44371-025-00195-y

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