Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings
Primary pulmonary synovial sarcoma (PPSS) is a rare malignancy. Its etiology, imaging features and optimal treatment are not well understood. Pulmonary pseudoaneurysms and lymphadenopathy are rare complications of synovial sarcomas. A 40-year-old woman with mild hemoptysis and thoracic back pain und...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/231043 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547724967280640 |
|---|---|
| author | Jaspreet S Kambo Bonnie Richardson Diana N Ionescu Tracy Tucker Greg Kraushaar |
| author_facet | Jaspreet S Kambo Bonnie Richardson Diana N Ionescu Tracy Tucker Greg Kraushaar |
| author_sort | Jaspreet S Kambo |
| collection | DOAJ |
| description | Primary pulmonary synovial sarcoma (PPSS) is a rare malignancy. Its etiology, imaging features and optimal treatment are not well understood. Pulmonary pseudoaneurysms and lymphadenopathy are rare complications of synovial sarcomas. A 40-year-old woman with mild hemoptysis and thoracic back pain underwent a computed tomography scan that revealed multiple pulmonary lesions, paraesophageal lymphadenopathy and incidental bilateral pulmonary emboli. A diagnosis of PPSS was made through the identification of an SS18 translocation by fluorescence in situ hybridization. She was started on adriamycin, ifosfamide and mesna chemotherapy. Over the subsequent two months, she developed three pulmonary artery pseudoaneurysms, ultimately requiring endovascular coiling. Seven months after starting treatment, the patient was asymptomatic. The lesions and lymphadenopathy decreased in size. The present case highlights complications of a rare malignancy and demonstrates positive response to ifosfamide-based chemotherapy in the setting of PPSS. |
| format | Article |
| id | doaj-art-a63ed2f6de66450fbf43672efa321929 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-a63ed2f6de66450fbf43672efa3219292025-02-03T06:43:47ZengWileyCanadian Respiratory Journal1198-22412015-01-01221e1e310.1155/2015/231043Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography FindingsJaspreet S Kambo0Bonnie Richardson1Diana N Ionescu2Tracy Tucker3Greg Kraushaar4Section of Internal Medicine, University of Saskatchewan, CanadaSection of Internal Medicine, University of Saskatchewan, CanadaBC Cancer Agency, Vancouver Centre, Vancouver, British Columbia, CanadaBC Cancer Agency, Vancouver Centre, Vancouver, British Columbia, CanadaRegina Qu’Appelle Health Region, Regina, Saskatchewan, CanadaPrimary pulmonary synovial sarcoma (PPSS) is a rare malignancy. Its etiology, imaging features and optimal treatment are not well understood. Pulmonary pseudoaneurysms and lymphadenopathy are rare complications of synovial sarcomas. A 40-year-old woman with mild hemoptysis and thoracic back pain underwent a computed tomography scan that revealed multiple pulmonary lesions, paraesophageal lymphadenopathy and incidental bilateral pulmonary emboli. A diagnosis of PPSS was made through the identification of an SS18 translocation by fluorescence in situ hybridization. She was started on adriamycin, ifosfamide and mesna chemotherapy. Over the subsequent two months, she developed three pulmonary artery pseudoaneurysms, ultimately requiring endovascular coiling. Seven months after starting treatment, the patient was asymptomatic. The lesions and lymphadenopathy decreased in size. The present case highlights complications of a rare malignancy and demonstrates positive response to ifosfamide-based chemotherapy in the setting of PPSS.http://dx.doi.org/10.1155/2015/231043 |
| spellingShingle | Jaspreet S Kambo Bonnie Richardson Diana N Ionescu Tracy Tucker Greg Kraushaar Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings Canadian Respiratory Journal |
| title | Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings |
| title_full | Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings |
| title_fullStr | Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings |
| title_full_unstemmed | Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings |
| title_short | Primary Pulmonary Synovial Sarcoma: A Case with Unique and Impressive Computed Tomography Findings |
| title_sort | primary pulmonary synovial sarcoma a case with unique and impressive computed tomography findings |
| url | http://dx.doi.org/10.1155/2015/231043 |
| work_keys_str_mv | AT jaspreetskambo primarypulmonarysynovialsarcomaacasewithuniqueandimpressivecomputedtomographyfindings AT bonnierichardson primarypulmonarysynovialsarcomaacasewithuniqueandimpressivecomputedtomographyfindings AT diananionescu primarypulmonarysynovialsarcomaacasewithuniqueandimpressivecomputedtomographyfindings AT tracytucker primarypulmonarysynovialsarcomaacasewithuniqueandimpressivecomputedtomographyfindings AT gregkraushaar primarypulmonarysynovialsarcomaacasewithuniqueandimpressivecomputedtomographyfindings |