Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P give insights into the structural mechanisms of hypertrophic cardiomyopathy

Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P give insights into the structural mechanisms of hypertrophic cardiomyopathy

Cardiac muscle α-actin is a key protein of the thin filament in the muscle sarcomere that, together with myosin thick filaments, produce force and contraction important for normal heart function. Missense mutations in cardiac muscle α-actin can cause hypertrophic cardiomyopathy, a complex disorder o...

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Bibliographic Details
Main Authors: Hsiang-Ling Huang, Andrejus Suchenko, Giovanna Grandinetti, Mohan K. Balasubramanian, Krishna Chinthalapudi, Sarah M. Heissler
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Cell Biology
Subjects:
Actin
Cytoskeleton
Mutation
Myosin
Hypertrophic cardiomyopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000773
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