Exploring novel of 1,2,4-triazolo[4,3-a]quinoxaline sulfonamide regioisomers as anti-diabetic and anti-Alzheimer agents with in-silico molecular docking simulation

Exploring novel of 1,2,4-triazolo[4,3-a]quinoxaline sulfonamide regioisomers as anti-diabetic and anti-Alzheimer agents with in-silico molecular docking simulation

Abstract In this study, a novel series of 1,2,4-triazolo[4,3-a]quinoxalines containing a sulfonamide moiety was designed and synthesized through regioselective synthesis from 2 and/ 3-hydrazino-6-(pyrrolidin-1-ylsulfonyl)quinoxaline derivatives 5 and 7. The structures of two isomers were confirmed a...

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Bibliographic Details
Main Authors: Moustafa S. Abusaif, Ahmed M. Sh El-Sharief, Yehia A. Mohamed, Yousry A. Ammar, Mostafa A. Ismail, Wael M. Aboulthana, Mohamed S. A. El-Gaby, Ahmed Ragab
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
1,2,4-triazolo[4,3-a]quinoxaline
Regioselective synthesis
Α-amylase and α-glucosidase inhibitors
Acetylcholinesterase inhibitors
Molecular docking simulation
Online Access:https://doi.org/10.1038/s41598-025-03139-9
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https://doi.org/10.1038/s41598-025-03139-9

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