Gut microbiota is involved in the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic animals by activation of the TLR4 pathway

Gut microbiota is involved in the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic animals by activation of the TLR4 pathway

IntroductionDiabetes induces glucocorticoid production in patients and animal models, however, the exact mechanism behind this phenomenon is still elusive. The activation of toll-like receptor (TLR) 4 induces glucocorticoid production by the adrenals. Since diabetic patients showed gut dysbiosis in...

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Main Authors: Nathalia Santos Magalhães, Amanda Silva Chaves, Beatriz Thomasi, Daniella Bianchi Reis Insuela, Heidi Pauer, Amanda Mendes Rêgo, Cristiane Cassiolato Pires Hardoim, Luis Caetano Martha Antunes, Patrícia Machado Rodrigues e Silva, Marco Aurélio Martins, Vinicius Frias Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Endocrinology
Subjects:
diabetes
gut microbiota
HPA axis
LPS
glucococorticoids
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1555203/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1555203/full

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