Rosmarinic acid potentiates gefitinib in lung adenocarcinoma by modulating interactions between cancer cells and cancer-associated fibroblasts

Rosmarinic acid potentiates gefitinib in lung adenocarcinoma by modulating interactions between cancer cells and cancer-associated fibroblasts

Abstract While cancer-associated fibroblasts (CAFs) significantly influence tumor progression, their temporal dynamics remain poorly understood. We investigated time-dependent interactions between non-small cell lung cancer (NSCLC) cells and CAFs, and evaluated rosmarinic acid (RA)’s potential to mo...

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Bibliographic Details
Main Authors: Duo Li, Yiying Lv, Leihao Hu, Anqi Sun, Lingling Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cancer-associated fibroblasts
Lung adenocarcinoma
Epithelial-mesenchymal transition
Rosmarinic acid
Temporal dynamics
Online Access:https://doi.org/10.1038/s41598-025-09755-9
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https://doi.org/10.1038/s41598-025-09755-9

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