A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment

A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment

In the field of cancer therapy, bispecific T cell engagers (BiTEs) have demonstrated significant potential. However, their clinical application is constrained by challenges in production and limited plasma half-life. In vitro-transcribed (IVT) mRNA formulations emerge as a promising alternative, off...

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Bibliographic Details
Main Authors: Giada Fiandaca, Elio Campanile, Lorena Leonardelli, Elisa Pettinà, Stefano Giampiccolo, Elizabeth J. Carstens, Lorenzo Dasti, Natascia Zangani, Luca Marchetti
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Bioinformatics
mRNA
lipid nanoparticles
nucleic acid delivery
physiologically based pharmacokinetic modeling
PBPK modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312500160X
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http://www.sciencedirect.com/science/article/pii/S216225312500160X

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