Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease

Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease

Abstract Introduction Free‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). Methods Sevent...

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Main Authors: Moto Nakaya, Noriko Sato, Hiroshi Matsuda, Norihide Maikusa, Yoko Shigemoto, Daichi Sone, Tensho Yamao, Masayo Ogawa, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Koichi Kato, Kyoji Okita, Tadashi Tsukamoto, Yuma Yokoi, Masuhiro Sakata, Osamu Abe
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
free‐water imaging
Centiloid scale
amyloid
tau
Online Access:https://doi.org/10.1002/trc2.12356
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https://doi.org/10.1002/trc2.12356

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