Rationally minimizing natural product libraries using mass spectrometry

Rationally minimizing natural product libraries using mass spectrometry

ABSTRACT Natural products are a critical source of novel chemotypes for drug discovery. However, the implementation of natural product extract libraries in high throughput screening is hampered by natural product structural redundancy and potential for bioactive re-discovery. This challenge and larg...

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Main Authors: Monica Ness, Thilini Peramuna, Karen L. Wendt, Jennifer E. Collins, Jarrod B. King, Raphaella Paes, Natalia Mojica Santos, Crystal Okeke, Cameron R. Miller, Debopam Chakrabarti, Robert H. Cichewicz, Laura-Isobel McCall
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mSystems
Subjects:
metabolomics
fungi
drug discovery
specialized metabolites
mass spectrometry
computational techniques
Online Access:https://journals.asm.org/doi/10.1128/msystems.00844-24
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https://journals.asm.org/doi/10.1128/msystems.00844-24

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