Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Abstract TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have been identified, little is known regarding the structural details of how they engage. To bette...

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Bibliographic Details
Main Authors: Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher L. M. Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jen Alexander-Brett, Tom J. Brett
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Neurodegeneration
Subjects:
TREM2
Microglia
IL-34
TDP-43
Complement C1q
apoE
Online Access:https://doi.org/10.1186/s13024-024-00795-9
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https://doi.org/10.1186/s13024-024-00795-9

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