Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a

Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a

BackgroundOsteoarthritis (OA) is a degenerative joint disease characterized by cartilage erosion, subchondral bone remodeling, and synovial inflammation. OA progression is driven by an imbalance between anabolic and catabolic activities in the cartilage extracellular matrix (ECM). Identifying molecu...

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Bibliographic Details
Main Authors: Mengyuan Dai, Jing Shi, Tao Wang, Sha Wan, Chen Fan, Siyu Wang, Siyuan Chen, Jiaojiao Shang, Qingquan Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
epigallocatechin-3-gallate
transcriptome sequencing
network pharmacology
Pla2g2a
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1624818/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1624818/full

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