Colchicine Enhances the Apoptotic, Anti-tumor Efficacy, Survival of Doxorubicin and Lowers Associated Toxicity in an Ehrlich Ascites Cancer Mouse Model

Colchicine Enhances the Apoptotic, Anti-tumor Efficacy, Survival of Doxorubicin and Lowers Associated Toxicity in an Ehrlich Ascites Cancer Mouse Model

Doxorubicin (DOX) is an effective chemotherapeutic drug, but induces serious adverse effects. The anti-inflammatory drug colchicine (COL) was found to inhibit inflammasome activity involved in DOX side effects. The purpose of this research to investigate COL impact when being added to DOX, if decrea...

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Bibliographic Details
Main Authors: Rana M. El-Tabakh, Eman F. Wasfey, Sophie Van Linthout, Nadia M. Hamdy, Mohamed L. Salem
Format: Article
Language:English
Published: Ain Shams University 2023-12-01
Series:Archives of Pharmaceutical Sciences Ain Shams University
Subjects:
colchicine
doxorubicin
ehrlich ascites carcinoma (eac)
antitumor
apoptosis
cell cycle
Online Access:https://aps.journals.ekb.eg/article_332152.html
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