Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

<h4>Background</h4>Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's dise...

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Main Authors: Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010405&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010405&type=printable

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