Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young

Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young

ABSTRACT Background Sarcopenia is thought to be underlined by age‐associated anabolic resistance and dysregulation of intracellular signalling pathways. However, it is unclear whether these phenomena are driven by ageing per se or other confounding factors. Methods Lean and healthy young (n = 10, 22...

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Main Authors: Oscar Horwath, Marcus Moberg, Nathan Hodson, Sebastian Edman, Mats Johansson, Eva Andersson, Gerrit vanHall, Olav Rooyackers, Andrew Philp, William Apró
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
amino acid sensing
cell signalling
protein synthesis
resistance exercise
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13613
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https://doi.org/10.1002/jcsm.13613

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