Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications
Abstract. This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer sur...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-01-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003419 |
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| _version_ | 1832593949858988032 |
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| author | Ali A. Alshahrani Evangelos Kontopantelis Catharine Morgan Rathi Ravindrarajah Glen P. Martin Mamas A. Mamas Rongman Jia |
| author_facet | Ali A. Alshahrani Evangelos Kontopantelis Catharine Morgan Rathi Ravindrarajah Glen P. Martin Mamas A. Mamas Rongman Jia |
| author_sort | Ali A. Alshahrani |
| collection | DOAJ |
| description | Abstract. This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer survival rates have improved over the last two decades, the risk of CVD has risen over time in patients with cancer. CVD and cancer share similar risk factors and a common pathophysiology involving inflammation. Many chemotherapeutic agents used to treat cancer are associated with cardiovascular complications (such as heart failure, myocardial infarction, and thrombosis). Current evidence indicates a significant burden of CVD in patients with cancer, particularly in the first year following cancer diagnosis, with elevated risk persisting beyond this period. This short- and long-term risk of CVD may vary depending on the cancer type and treatment regimen. Early identification of potential cardiovascular risk in patients with cancer, can lead to more favorable clinical and survival outcomes. Given the acute and long-term consequences, patients with cancer require increased cardiovascular care and lifestyle optimization. This article offers valuable insights into the cardiovascular burden and needs of patients with cancer. It is intended for a general medical research readership interested in the intersection of cardiology and oncology. |
| format | Article |
| id | doaj-art-a59d336c3b204afbb82c88b7e65a7503 |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-a59d336c3b204afbb82c88b7e65a75032025-01-20T07:56:42ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-01-01138214315410.1097/CM9.0000000000003419202501200-00003Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implicationsAli A. Alshahrani0Evangelos Kontopantelis1Catharine Morgan2Rathi Ravindrarajah3Glen P. Martin4Mamas A. Mamas5Rongman Jia1 Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester M13 9QQ, United Kingdom1 Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester M13 9QQ, United Kingdom1 Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester M13 9QQ, United Kingdom1 Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester M13 9QQ, United Kingdom1 Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester M13 9QQ, United Kingdom3 Keele Cardiovascular Research Group, Institute for Prognosis Research, University of Keele, Keele ST5 5BG, United KingdomAbstract. This article provides an overview of the current evidence on the epidemiology, overlapping risk factors, and pathophysiology of cardiovascular disease (CVD) in patients with cancer. It explores the cardiotoxic effects of anticancer therapy and their impact on prognosis. Although cancer survival rates have improved over the last two decades, the risk of CVD has risen over time in patients with cancer. CVD and cancer share similar risk factors and a common pathophysiology involving inflammation. Many chemotherapeutic agents used to treat cancer are associated with cardiovascular complications (such as heart failure, myocardial infarction, and thrombosis). Current evidence indicates a significant burden of CVD in patients with cancer, particularly in the first year following cancer diagnosis, with elevated risk persisting beyond this period. This short- and long-term risk of CVD may vary depending on the cancer type and treatment regimen. Early identification of potential cardiovascular risk in patients with cancer, can lead to more favorable clinical and survival outcomes. Given the acute and long-term consequences, patients with cancer require increased cardiovascular care and lifestyle optimization. This article offers valuable insights into the cardiovascular burden and needs of patients with cancer. It is intended for a general medical research readership interested in the intersection of cardiology and oncology.http://journals.lww.com/10.1097/CM9.0000000000003419 |
| spellingShingle | Ali A. Alshahrani Evangelos Kontopantelis Catharine Morgan Rathi Ravindrarajah Glen P. Martin Mamas A. Mamas Rongman Jia Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications Chinese Medical Journal |
| title | Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications |
| title_full | Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications |
| title_fullStr | Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications |
| title_full_unstemmed | Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications |
| title_short | Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications |
| title_sort | cardiovascular diseases in patients with cancer a comprehensive review of epidemiological trends cardiac complications and prognostic implications |
| url | http://journals.lww.com/10.1097/CM9.0000000000003419 |
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