Stabilizing Prefusion SARS-CoV-2 Spike by Destabilizing the Postfusion Conformation

Stabilizing Prefusion SARS-CoV-2 Spike by Destabilizing the Postfusion Conformation

<b>Background/Objectives:</b> As with many viral fusion proteins, the native conformation of SARS-CoV-2 Spike is metastable. Most COVID-19 vaccines utilize a stabilized Spike (Spike-2P) containing two proline substitutions, and subsequently, a further stabilized variant with four additio...

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Bibliographic Details
Main Authors: Debajyoti Chakraborty, Randhir Singh, Raju S. Rajmani, Sahil Kumar, Rajesh P. Ringe, Raghavan Varadarajan
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
stabilization
SARS-CoV-2 Spike
charged amino acids
HR1 and HR2
immunogenicity
COVID-19
Online Access:https://www.mdpi.com/2076-393X/13/3/315
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