A potent phenylalkylamine disrupts mycobacterial membrane bioenergetics and augments bactericidal activity of bedaquiline

A potent phenylalkylamine disrupts mycobacterial membrane bioenergetics and augments bactericidal activity of bedaquiline

Summary: Clinically efficacious combination therapies capable of impeding resistance are widely sought for the treatment of mycobacterial infections. Here, we described structural modifications of the phenylalkylamine scaffold of verapamil to give an analog with more than 10-fold greater growth inhi...

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Bibliographic Details
Main Authors: Zheng Yen Phua, Ming Li, Azhar Ali, Cedric Cheng Sheng Cheong, Kai Jie Goh, Marcus Yi Kang Seto, Amos Shi Ying Ng, Jickky Palmae Sarathy, Boon Cher Goh, Mei Lin Go, Wai Keung Chui, Thomas Dick, Yulin Lam
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Chemistry
Biological sciences
Energy engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011769
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http://www.sciencedirect.com/science/article/pii/S2589004225011769

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