Primary amenorrhoea - cytogenetic study in 40 Indian women
Background Primary amenorrhoea (PA) refers to an ailment when adolescent girls do not attain menarche naturally. It is one of the most common gynaecological disorders specified. Chromosomal abnormalities play a pivotal role in PA. Cytogenetic analysis is an indispensable diagnostic tool to determine...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2348085 |
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| author | Byapti Banerjee Atreyee Dutta Sanchita Roy Ajanta Halder |
| author_facet | Byapti Banerjee Atreyee Dutta Sanchita Roy Ajanta Halder |
| author_sort | Byapti Banerjee |
| collection | DOAJ |
| description | Background Primary amenorrhoea (PA) refers to an ailment when adolescent girls do not attain menarche naturally. It is one of the most common gynaecological disorders specified. Chromosomal abnormalities play a pivotal role in PA. Cytogenetic analysis is an indispensable diagnostic tool to determine the abnormality of the chromosome. In an emerging country like India, cytogenetic analysis is at a nascent stage. There are very few studies on Cytogenetics present in eastern India, including West Bengal. In rural and suburban areas PA sufferers often experience late diagnosis and struggle to access suitable curative management. The aim of the study is to evaluate the various types of chromosomal abnormalities in patients suffering from PA for accurate, better management of the same and further counselling.Methods A total of 40 PA cases were referred by obstetricians and gynaecologists to the Department of Genetics of Nirnayan Health Care, Kolkata. To screen the chromosomal abnormalities, human leukocyte culture was accomplished with their peripheral venous blood followed by G-banding and then karyotyping was executed according to ISCN-2020.Result Out of 40 patients, 29 were normal among which 46,XX was found in 70% cases (n = 28) and 46,XX,9qh + in 2.5% (n = 1). The remaining 11 showed different types of abnormalities. 45,X was found in 10% (n = 4), 46,X,i(X)(q10) in 2.5% (n = 1), 46,X,del(X)(p11.2) in 2.5% (n = 1), 46,X,del(X)(p22.1) in 2.5% (n = 1), 46,X,del(X)(q24) in 2.5% (n = 1), 46,XY in 2.5% (n = 1), mos 45,X[22]/46,Xi(X)(q.10)[8] in 2.5% (n = 1) and mos 45,X[16]/46,XY[14] (2.5%) in 2.5% (n = 1).Conclusion This study indicates the importance of chromosomal study which must be included in early diagnosis of PA. Karyotyping at the appropriate phase of life will not only help in the judicial management of this disorder but will also give young girls a better lifestyle. |
| format | Article |
| id | doaj-art-a55da09805db453cb09b435a99ac553b |
| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-a55da09805db453cb09b435a99ac553b2025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2348085Primary amenorrhoea - cytogenetic study in 40 Indian womenByapti Banerjee0Atreyee Dutta1Sanchita Roy2Ajanta Halder3Department of Genetics, Nirnayan Healthcare Pvt. Ltd, Kolkata, IndiaDepartment of Genetics, Nirnayan Healthcare Pvt. Ltd, Kolkata, IndiaDepartment of Genetics, Nirnayan Healthcare Pvt. Ltd, Kolkata, IndiaDepartment of Genetics, Nirnayan Healthcare Pvt. Ltd, Kolkata, IndiaBackground Primary amenorrhoea (PA) refers to an ailment when adolescent girls do not attain menarche naturally. It is one of the most common gynaecological disorders specified. Chromosomal abnormalities play a pivotal role in PA. Cytogenetic analysis is an indispensable diagnostic tool to determine the abnormality of the chromosome. In an emerging country like India, cytogenetic analysis is at a nascent stage. There are very few studies on Cytogenetics present in eastern India, including West Bengal. In rural and suburban areas PA sufferers often experience late diagnosis and struggle to access suitable curative management. The aim of the study is to evaluate the various types of chromosomal abnormalities in patients suffering from PA for accurate, better management of the same and further counselling.Methods A total of 40 PA cases were referred by obstetricians and gynaecologists to the Department of Genetics of Nirnayan Health Care, Kolkata. To screen the chromosomal abnormalities, human leukocyte culture was accomplished with their peripheral venous blood followed by G-banding and then karyotyping was executed according to ISCN-2020.Result Out of 40 patients, 29 were normal among which 46,XX was found in 70% cases (n = 28) and 46,XX,9qh + in 2.5% (n = 1). The remaining 11 showed different types of abnormalities. 45,X was found in 10% (n = 4), 46,X,i(X)(q10) in 2.5% (n = 1), 46,X,del(X)(p11.2) in 2.5% (n = 1), 46,X,del(X)(p22.1) in 2.5% (n = 1), 46,X,del(X)(q24) in 2.5% (n = 1), 46,XY in 2.5% (n = 1), mos 45,X[22]/46,Xi(X)(q.10)[8] in 2.5% (n = 1) and mos 45,X[16]/46,XY[14] (2.5%) in 2.5% (n = 1).Conclusion This study indicates the importance of chromosomal study which must be included in early diagnosis of PA. Karyotyping at the appropriate phase of life will not only help in the judicial management of this disorder but will also give young girls a better lifestyle.https://www.tandfonline.com/doi/10.1080/01443615.2024.2348085Primary amenorrhoeaChromosomal abnormalitiesGenetic counsellingKaryotyping |
| spellingShingle | Byapti Banerjee Atreyee Dutta Sanchita Roy Ajanta Halder Primary amenorrhoea - cytogenetic study in 40 Indian women Journal of Obstetrics and Gynaecology Primary amenorrhoea Chromosomal abnormalities Genetic counselling Karyotyping |
| title | Primary amenorrhoea - cytogenetic study in 40 Indian women |
| title_full | Primary amenorrhoea - cytogenetic study in 40 Indian women |
| title_fullStr | Primary amenorrhoea - cytogenetic study in 40 Indian women |
| title_full_unstemmed | Primary amenorrhoea - cytogenetic study in 40 Indian women |
| title_short | Primary amenorrhoea - cytogenetic study in 40 Indian women |
| title_sort | primary amenorrhoea cytogenetic study in 40 indian women |
| topic | Primary amenorrhoea Chromosomal abnormalities Genetic counselling Karyotyping |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2348085 |
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