Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches

Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches

Abstract Cyclin-dependent kinases (CDKs) are crucial for controlling the cell cycle, and many malignancies are linked to CDK dysfunction. Therefore, CDKs are desirable targets for cancer treatment. Since abnormal expression of CDK4/6 is the etiology of glioblastoma, it is imperative to investigate t...

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Main Authors: Hina Manzoor, Muhammad Umer Khan, Raima Rehman, Chaudhry Ahmed Shabbir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Ayman Ali Mohammed Alameen, Muhammad Arshad Javed, Qurban Ali, Nazima Haider
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
CDK6
LBVS
Molecular Docking
Pharmacokinetics
Density functional theory
MD simulation
Online Access:https://doi.org/10.1038/s41598-025-10744-1
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https://doi.org/10.1038/s41598-025-10744-1

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