Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

Rapid and high-fidelity phosphorylation of serine residues at positions 32 and 36 of IκBα by IKK2/β, a highly conserved prototypical Ser/Thr kinase in vertebrates, is critical for canonical NF-κB activation. Here, we report that human IKK2 not only phosphorylates substrate serine residues and autoph...

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Bibliographic Details
Main Authors: Prateeka Borar, Tapan Biswas, Ankur Chaudhuri, Pallavi T Rao, Swasti Raychaudhuri, Tom Huxford, Saikat Chakrabarti, Gourisankar Ghosh, Smarajit Polley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
protein kinase
phosphorylation
signal transduction
Online Access:https://elifesciences.org/articles/98009
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https://elifesciences.org/articles/98009

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