Integration of scRNA-seq and bulk RNA-seq to reveal the association and potential molecular mechanisms of metabolic reprogramming regulated by lactylation and chemotherapy resistance in ovarian cancer

Integration of scRNA-seq and bulk RNA-seq to reveal the association and potential molecular mechanisms of metabolic reprogramming regulated by lactylation and chemotherapy resistance in ovarian cancer

ObjectiveOvarian cancer (OC) ranks among the foremost causes of mortality in gynecological malignancies, with chemoresistance being the primary factor contributing to unfavorable prognosis. This work seeks to clarify the mechanisms of resistance-related lactylation in OC, intending to offer novel th...

Full description

Saved in:
Bibliographic Details
Main Authors: Fang Ren, Xiaoao Pang, Feng Jin, Nannan Luan, Houhua Guo, Liancheng Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
chemoresistance
lactylation
single cell sequencing
metabolic pathways
S100A4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513806/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513806/full

Similar Items