Selective Synthesis of Tetrahydroisoquinoline and Piperidine Scaffolds by Oxidative Ring Opening/Ring Closing Protocols of Substituted Indenes and Cyclopentenes

Selective Synthesis of Tetrahydroisoquinoline and Piperidine Scaffolds by Oxidative Ring Opening/Ring Closing Protocols of Substituted Indenes and Cyclopentenes

Abstract Novel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates. By a ring‐closing step using chiral (R) or (S)...

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Bibliographic Details
Main Authors: Anas Semghouli, László Drahos, Jianlin Han, Loránd Kiss, Melinda Nonn
Format: Article
Language:English
Published: Wiley-VCH 2025-05-01
Series:ChemistryOpen
Subjects:
Cyclization
Ring expansion
Ring opening
Ring closing
Piperidine
Tetrahydroisoquinoline
Online Access:https://doi.org/10.1002/open.202400475
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https://doi.org/10.1002/open.202400475

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