Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of Muc4

Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of Muc4

Tubulointerstitial fibrosis (TIF) is the common final outcome of almost all progressive chronic kidney diseases (CKDs). Hypoxia-inducible factor-1 (HIF-1) activation plays an essential role in CKD; however, the specific contribution of tubular HIF-1 to renal TIF remains unclear. In the current study...

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Bibliographic Details
Main Authors: Zhong-Tang Li, Xin-Hui Hu, Wei-Jie Ni, Zuo-Lin Li, Bi-Kun Huang, Yu Zhang, A-Feng Miao, Jing-Yuan Cao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Tubulointerstitial fibrosis
HIF-1α
Muc4
chronic kidney disease
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2501757
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2501757

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