Association of antibody and T cell receptor repertoires in Trypanosoma cruzi infected rhesus macaques and host response to infection

Association of antibody and T cell receptor repertoires in Trypanosoma cruzi infected rhesus macaques and host response to infection

Abstract Background Chagas disease, caused by Trypanosoma cruzi parasites, leads to chronic cardiac disease in 20–40% of infected patients, while the majority remain asymptomatic. The mechanisms and drivers of pathogenesis are still poorly understood, limiting treatment options. We tested for differ...

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Bibliographic Details
Main Authors: Rachel M. Clear, Weihong Tu, Kelly Goff, Preston A. Marx, Claudia Herrera, Eric Dumonteil
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Biomedical Science
Subjects:
Chagas disease
Adaptive response
CDR3
Pathogenesis
Chronic infection
Online Access:https://doi.org/10.1186/s12929-025-01152-8
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https://doi.org/10.1186/s12929-025-01152-8

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