Model-Informed Dose Optimization of Spironolactone in Neonates and Infants

Model-Informed Dose Optimization of Spironolactone in Neonates and Infants

<b>Background/Objectives</b>: Spironolactone (SP) has been used off-label in pediatrics since its approval, but its use is challenged by limited pharmacokinetic (PK) data in adults and especially in children. <b>Methods</b>: Physiologically based pharmacokinetic (PBPK) models...

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Bibliographic Details
Main Authors: Amira Soliman, Leandro F. Pippa, Jana Lass, Stephanie Leroux, Valvanera Vozmediano, Natalia V. de Moraes
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
PBPK
infants
pediatrics
spironolactone
dose optimization
Online Access:https://www.mdpi.com/1424-8247/18/3/355
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