Abacavir enhances the efficacy of doxorubicin via inhibition of histone demethylase KDM5B in breast cancer

Abacavir enhances the efficacy of doxorubicin via inhibition of histone demethylase KDM5B in breast cancer

Abstract KDM5B, a lysine-specific histone demethylase, is widely upregulated in breast cancer. The current study investigated the role of KDM5B in breast cancer and explored the repurposing potential of the antiviral drug abacavir (ABC). The cytotoxic effects and the effect of ABC sensitization on d...

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Main Authors: Anmi Jose, Pallavi Kulkarni, Naveena AN Kumar, Nawaz Usman, Gabriel Sunil Rodrigues, Gautham G. Shenoy, Rama Rao Damerla, Murali Munisamy, Bharti Bisht, Sooryanarayana Varambally, Manash K. Paul, Neha Arya, Praveen PN Rao, Mahadev Rao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Breast cancer
Carbovir triphosphate
Drug repurposing
Epigenetic targeting
Precision medicine
Online Access:https://doi.org/10.1038/s41598-025-13845-z
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https://doi.org/10.1038/s41598-025-13845-z

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