Development of a multi-neoepitope vaccine targeting non-small cell lung cancer through reverse vaccinology and bioinformatics approaches

Development of a multi-neoepitope vaccine targeting non-small cell lung cancer through reverse vaccinology and bioinformatics approaches

IntroductionLung cancer, predominantly non-small cell lung cancer (NSCLC), is the leading cause of cancer-related mortality worldwide. Among immunotherapeutic strategies, the personalized multi-neoepitope vaccine (MNEV) offers a promising approach for managing advanced-stage NSCLC.MethodsWe used rev...

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Bibliographic Details
Main Authors: Elahe Asadollahi, Alireza Zomorodipour, Zahra-Soheila Soheili, Babak Jahangiri, Majid Sadeghizadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
NSCLC
immunotherapy
targeted treatments
tumor-specific antigens
neoantigens
reverse vaccinology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521700/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521700/full

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