Facilitating DNAzyme transport across the blood-brain barrier with nanoliposome technology

Facilitating DNAzyme transport across the blood-brain barrier with nanoliposome technology

Abstract Recently, oligonucleotide post-transcriptional gene silencing, antisense oligonucleotides, small interfering RNA, ribozymes, and Deoxyribozymes (DNAzymes) have been used to tackle neurodegenerative diseases such as Alzheimer’s and polyglutamine diseases like Huntington’s disease. However, t...

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Bibliographic Details
Main Authors: Mohammad Javad Hoseinifar, Faranak Aghaz, Zahra Asadi, Peyman Asadi, Seyed Ershad Nedaei, Elham Arkan, Ali Pourmotabbed, Gholamreza Bahrami, Tayebeh Pourmotabbed
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
DNAzyme
Blood-Brain barrier
Nanoliposome
BBB permeability
Online Access:https://doi.org/10.1038/s41598-025-04433-2
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https://doi.org/10.1038/s41598-025-04433-2

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