Exploring murE protein inhibitors of Tropheryma whipplei through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights

Tropheryma whipplei the causative agent of Whipple disease, presents a diagnostic challenge due to its diverse symptomatology, including weight loss, abdominal pain, diarrhea, joint pain, fever, and occasionally neurological manifestations. Its resistance to fluoroquinolones complicates treatment fu...

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Bibliographic Details
Main Authors: Zarrin Basharat, Calvin R. Wei, Madiha Islam, Ibrar Ahmed, Hanan A. Ogaly, Fatimah A. M. Al-Zahrani, Yasir Waheed, Seil Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1630038/full
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