Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

Abstract The efficacy of T-cell-based cancer therapies can be limited by the tumor microenvironment which can lead to T cell dysfunction. Multiple studies, particularly in murine models, have demonstrated the capacity of the aryl hydrocarbon receptor (AHR) to negatively regulate antitumor T cell fun...

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Main Authors: Valentine De Castro, Oumaïma Abdellaoui, Barbara Dehecq, Babacar Ndao, Patricia Mercier-Letondal, Alexandra Dauvé, Francine Garnache-Ottou, Olivier Adotévi, Romain Loyon, Yann Godet
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
AHR
T cell dysfunction
CRISPR-Cas9
CAR-T cell therapy
Online Access:https://doi.org/10.1007/s00262-025-04065-5
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https://doi.org/10.1007/s00262-025-04065-5

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