The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease

The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease

Abstract Background Variants of SORL1 have been associated with both late and early onset of Alzheimer’s disease (AD). SORL1 encodes the sorting-related receptor with A repeat (SORLA) protein, which belongs to the VPS10 receptor family. SORLA protects against AD pathogenesis through its sorting func...

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Main Authors: Hasibur Rehman, Shun Yan, Shalini Saggu, Mae Aida, Fang Zhang, Yang Shu, Alexis Jones, Amy Trang, Emily Dew, Wenbo Zhi, Emily T. Claeboe, Anthony J. Baucum, Guangyu Wu, Kai Jiao, Qin Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
SORLA
PKCι/λ
βarrestin2
Alzheimer’s disease
Protein–protein interaction
Trafficking
Online Access:https://doi.org/10.1186/s13024-025-00865-6
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https://doi.org/10.1186/s13024-025-00865-6

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