Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

IntroductionRecent findings reveal that the precursors of exhausted CD8+ T (CD8+ Tpex) cells possess stem-like signatures in tumor immunity, which originate from tumor draining lymph node (TdLN)-derived tumor-specific memory (CD8+ TTSM) cells. Both of these T subsets can be collectively referred to...

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Bibliographic Details
Main Authors: Xiaokang Ruan, Linwei Wu, Zijian Tang, Yao Li, Jin Wang, Haolin Jiang, Li Zhang, Shengjia Wang, Zhaoqiang Chen, Chenlei Yuan, Yujian Xia, Yan Pan, Jianling Gao, Xin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
chemotherapeutic agents
CD62L+ CD8+ Tpex cells
CD8+ TTSM cells
Eomes
antitumor immune responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1533857/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1533857/full

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