Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy

Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy

<b>Background/Objectives</b>: Triple-negative breast cancer (TNBC) is a major cause of cancer-related deaths among women. The Hedgehog (Hh) signaling pathway plays a critical role in tumor development, and targeting this pathway may provide new therapeutic opportunities for TNBC. TPB15 i...

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Main Authors: Dingsheng Wen, Boyu Chen, Mingtong Deng, Shaoyu Wu, Shuilin Xie
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
TPB15
metabolic enzyme phenotype
plasma protein binding
species different
metabolite
Online Access:https://www.mdpi.com/1999-4923/17/4/423
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