An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits

An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits

Abstract Background Quantitative measures of autism spectrum disorder (ASD)-related traits can provide insight into trait presentation across the population. Previous studies have identified epigenomic variation associated with ASD diagnosis, but few have evaluated quantitative traits. We sought to...

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Main Authors: Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Autism
Social Responsiveness Scale
DNA methylation
Quantitative trait
Online Access:https://doi.org/10.1186/s11689-025-09637-1
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https://doi.org/10.1186/s11689-025-09637-1

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