Designing of a novel chimeric antimicrobial peptide against Acinetobacter baumannii using three different bioinformatics methods and evaluation of its antimicrobial activity in vitro

Designing of a novel chimeric antimicrobial peptide against Acinetobacter baumannii using three different bioinformatics methods and evaluation of its antimicrobial activity in vitro

Background and purpose: The study aimed to design new chimeric antimicrobial peptides targeting Acinetobacter baumannii, a widespread and growing global concern due to antibiotic resistance. Three bioinformatics-based methods were utilized for this purpose. Experimental approach: To design new chime...

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Bibliographic Details
Main Authors: Yasin Rakhshani, Jafar Amani, Hamideh Mahmoodzadeh Hosseini, Seyed Ali Mirhosseini, Fattah Sotoodeh Nejad Nematalahi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-03-01
Series:Research in Pharmaceutical Sciences
Subjects:
acinetobacter baumanni
antimicrobial peptide
drug design
hybrid peptides
model membrane
web servers
Online Access:https://journals.lww.com/10.4103/RPS.RPS_70_23
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https://journals.lww.com/10.4103/RPS.RPS_70_23

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